abstract：:Exposure to a dry environment leads to depletion of water from the peripheral stratum corneum layers in a process dependent on the relative humidity (RH) and the intrinsic properties of the tissue. We hypothesized that by modulating the water content of the stratum corneum in the surface layers, RH effects the rate of...

journal_title：Archives of dermatological research

authors： Watkinson A,Harding C,Moore A,Coan P

更新日期：2001-09-01 00:00:00

abstract：:Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulat...

journal_title：Archives of dermatological research

authors： Tanaka N,Tajima S,Ishibashi A,Uchida K,Shigematsu T

更新日期：2001-07-01 00:00:00

abstract：:Previous studies have demonstrated that permeability barrier disruption by acetone treatment significantly enhances skin permeability to both hydrophilic and amphipathic compounds, but not to highly lipophilic compounds. The purpose of the present study was to investigate the dependence of permeability on molecular we...

journal_title：Archives of dermatological research

authors： Tsai JC,Hung PL,Sheu HM

更新日期：2001-06-01 00:00:00

abstract：:GM-CSF is known primarily as a hematopoietic growth factor, but it has also been shown to inhibit mast cell differentiation in vitro. In order elucidate the mechanisms involved, we investigated the effects of GM-CSF in vitro on the differentiation of human leukemic mast cells (HMC-1 cells) and normal cord blood-derive...

journal_title：Archives of dermatological research

authors： Welker P,Grabbe J,Zuberbier T,Grützkau A,Henz BM

更新日期：2001-05-01 00:00:00

abstract：:Recently, medium-dose UVA1 phototherapy (50 J/cm2) has been introduced as an effective treatment for severe atopic dermatitis (AD). In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement in skin status in patients with AD, biopsy specimens from ten patients before an...

journal_title：Archives of dermatological research

authors： Breuckmann F,Pieck C,Kreuter A,Bacharach-Buhles M,Mannherz HG,Altmeyer P,von Kobyletzki G

更新日期：2001-04-01 00:00:00

abstract：:The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate. We studied 187 women with alopecia, which we graded I, II, or III, according to Ludwig's classification, and 21 healthy control women. All participants were subjected to...

journal_title：Archives of dermatological research

authors： Vexiau P,Chaspoux C,Boudou P,Fiet J,Abramovici Y,Rueda MJ,Hardy N,Reygagne P

更新日期：2000-12-01 00:00:00

abstract：:This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...

journal_title：Archives of dermatological research

authors： Vasků V,Vasků A,Izakovicová Hollá L,Tschöplová S,Kanková K,Benáková N,Semrádová V

更新日期：2000-11-01 00:00:00

abstract：:Thrombin has recently been shown not only to exert procoagulant activities, but also to induce mitogenic responses of different cell types involved in wound healing via binding to and cleavage of the thrombin receptor. In order to further explore these aspects of thrombin function, human keratinocytes (HaCaT cell line...

journal_title：Archives of dermatological research

authors： Algermissen B,Sitzmann J,Nürnberg W,Laubscher JC,Henz BM,Bauer F

更新日期：2000-10-01 00:00:00

abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...

journal_title：Archives of dermatological research

authors： Meguro S,Arai Y,Masukawa Y,Uie K,Tokimitsu I

更新日期：2000-09-01 00:00:00

abstract：:It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...

journal_title：Archives of dermatological research

authors： Johansson O,Liang Y,Marcusson JA,Reimert CM

更新日期：2000-08-01 00:00:00

abstract：:In the study described here we investigated the possibility of an association between the aggressiveness of melanoma and multidrug resistance phenotype by analyzing the expression and activity of P-glycoprotein (Pgp) in two genetically related transplantable hamster melanomas--a melanotic (Ma) and an amelanotic (Ab) f...

journal_title：Archives of dermatological research

authors： Witkowski JM,Kozłowska K,Zarzeczna M

更新日期：2000-07-01 00:00:00

abstract：:The incidence of epithelioid sarcoma among patients with malignant soft tissue tumors is small, but the rates of recurrence and metastasis of this type of sarcoma are high. To date, effective chemotherapy for advanced epithelioid sarcoma has not been established and, furthermore, epithelioid sarcoma is known to exhibi...

journal_title：Archives of dermatological research

authors： Kusakabe H,Iwasaki H,Sano K,Kiyokane K

更新日期：2000-06-01 00:00:00

abstract：:Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via ...

journal_title：Archives of dermatological research

authors： Leiter U,Schmid RM,Kaskel P,Peter RU,Krähn G

更新日期：2000-05-01 00:00:00

abstract：:The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at...

journal_title：Archives of dermatological research

authors： Tanaka T,Narisawa Y

更新日期：2000-04-01 00:00:00

abstract：:In human skin, epidermal differentiation occurs in two ways: normal differentiation, characterized by keratin 10 expression, and alternative differentiation. Alternative differentiation can be hyperproliferation-associated differentiation (expression of keratin 16) or the reinduction of an embryonic type of differenti...

journal_title：Archives of dermatological research

authors： van Rossum MM,Mommers JM,van de Kerkhof PC,van Erp PE

更新日期：2000-01-01 00:00:00

abstract：:Human alpha 1(I) and alpha 1(III) procollagen mRNA expression in skin tissue from 15 systemic sclerosis (SSc) patients and from 7 normal control subjects was quantitatively analyzed using in situ hybridization. The grains accumulating in each area, representing procollagen mRNA expression per cell, were counted. To no...

journal_title：Archives of dermatological research

authors： Ohtsuka T,Koibuchi N,Sakai H,Yamakage A,Yamazaki S

更新日期：1999-11-01 00:00:00

abstract：:Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...

journal_title：Archives of dermatological research

authors： Shimizu H,Masunaga T,Kurihara Y,Owaribe K,Wiche G,Pulkkinen L,Uitto J,Nishikawa T

更新日期：1999-10-01 00:00:00

abstract：:Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...

journal_title：Archives of dermatological research

authors： Komine M,Watabe Y,Shimaoka S,Sato F,Kake K,Nishina H,Ohtsuki M,Nakagawa H,Tamaki K

更新日期：1999-09-01 00:00:00

abstract：:Linoleic acid is required for the formation and maintenance of the epidermal barrier, but most of the current in vitro keratinocyte culture systems are linoleic acid-deficient. The aim of the present study was to examine the efficiency of linoleic acid uptake in human keratinocyte cultures grown under submerged and ai...

journal_title：Archives of dermatological research

authors： Vicanová J,Weerheim AM,Kempenaar JA,Ponec M

更新日期：1999-07-01 00:00:00

abstract：:HaCaT keratinocytes differ from normal human epidermal keratinocytes (HEK) by constitutive expression of differentiation markers which are normally suppressed by vitamin A. In search of an explanation for this discrepancy we compared the vitamin A content, the expression of retinoid-binding proteins, and the vitamin A...

journal_title：Archives of dermatological research

authors： Törmä H,Rollman O,Vahlquist A

更新日期：1999-06-01 00:00:00

abstract：:Murine mast cell proliferation and maturation are regulated by two distinct cytokines, interleukin-3 (IL-3) and the c-kit ligand, stem cell factor (SCF). In this study using cells of the mouse mast cell line, MC/9, the effects of two immunosuppressants, FK506 and cyclosporin A (CsA), were investigated. Withdrawal of I...

journal_title：Archives of dermatological research

authors： Ito F,Toyota N,Sakai H,Takahashi H,Iizuka H

更新日期：1999-05-01 00:00:00

abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...

journal_title：Archives of dermatological research

authors： Sakai H,Toyota N,Ito F,Takahashi H,Hashimoto Y,Iizuka H

更新日期：1999-04-01 00:00:00

abstract：:A number of studies have demonstrated an increased frequency of allergen-specific T cells producing increased amounts of interleukin-4 (IL-4) and IL-5, but little interferon-y in both the peripheral blood and skin lesions of patients with atopic dermatitis (AD). In this study, to further clarify the characteristics of...

journal_title：Archives of dermatological research

authors： Kawamura MS,Aiba S,Tagami H

更新日期：1998-11-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) is regularly expressed or inducible on all major cutaneous cell populations including Langerhans cells, keratinocytes, endothelial cells and dermal fibroblasts. ICAM-1 is induced in the skin under inflammatory conditions and plays an important role in the activation of T cell...

journal_title：Archives of dermatological research

authors： Chatelain R,Wollenberg A,Martin C,Panhans-Gross A,Bieber T,Degitz K,Heckmann M

更新日期：1998-09-01 00:00:00

abstract：:Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of...

journal_title：Archives of dermatological research

authors： Madlener M

更新日期：1998-07-01 00:00:00

abstract：:Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...

journal_title：Archives of dermatological research

authors： Saalbach A,Kraft R,Herrmann K,Haustein UF,Anderegg U

更新日期：1998-07-01 00:00:00

abstract：:The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = ...

journal_title：Archives of dermatological research

authors： Greiner JV,Glonek T,Townsend DJ,Hearn SL

更新日期：1998-06-01 00:00:00

abstract：:Investigations on the nutrient requirements of Malassezia yeasts led to the preparation of a new minimal medium consisting of an amino nitrogen and a lipid source, which only allowed the growth of the species M. furfur. Carbohydrates, electrolytes, vitamins and trace elements were not required. Using the basal medium,...

journal_title：Archives of dermatological research

authors： Mayser P,Imkampe A,Winkeler M,Papavassilis C

更新日期：1998-05-01 00:00:00

abstract：:The aim of the present study was to investigate the influence of three different retinoids, isotretinoin, etretinate and acitretin, on the mitogenic response of peripheral blood mononuclear cells (PBMCs) to PHA and PMA in vitro. All three retinoids at high concentrations (10(-4)M) significantly inhibited the mitogenic...

journal_title：Archives of dermatological research

authors： Chaidaroglou A,Degiannis D,Koniavitou K,Georgiou S,Tsambaos D

更新日期：1998-04-01 00:00:00

abstract：:It has been reported that artificial restoration of barrier function by a water vapor-impermeable membrane after tape stripping induces barrier abrogation in hairless mice, impeding rather than enhancing barrier recovery. To address this issue, we examined the morphologic changes in the epidermis after tape stripping ...

journal_title：Archives of dermatological research

authors： Jiang S,Koo SW,Lee SH

更新日期：1998-03-01 00:00:00

abstract：:Immigration of neutrophils into the epidermis is a hallmark of several so-called neutrophilic dermatoses. In this study we used a frozen section adhesion assay to study the impact of different activation procedures as well as of CD11 integrins on cell-cell adhesion between neutrophils and epidermal cells. Serial secti...

journal_title：Archives of dermatological research

authors： von den Driesch P,Weller M,Wörl P

更新日期：1997-11-01 00:00:00

abstract：:The aim of this study was to characterize the swelling behaviour of the stratum corneum. Stratum corneum pieces isolated from the breast region of 20 different females were incubated in distilled water at two different temperatures (20 degrees C and 45 degrees C) for 90 min and 24 h, respectively. Half of the stratum ...

journal_title：Archives of dermatological research

authors： Norlén L,Emilson A,Forslind B

更新日期：1997-08-01 00:00:00

abstract：:The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...

journal_title：Archives of dermatological research

authors： Beljaards RC,Van Beek P,Nieboer C,Stoof TJ,Boorsma DM

更新日期：1997-07-01 00:00:00

abstract：:Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. However, there are no reports concerning the effect of DHEA on the production of Th2-associated lymphokines, IL-4 ...

journal_title：Archives of dermatological research

authors： Tabata N,Tagami H,Terui T

更新日期：1997-06-01 00:00:00

abstract：:Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...

journal_title：Archives of dermatological research

authors： Benathan M

更新日期：1997-05-01 00:00:00

abstract：:Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...

journal_title：Archives of dermatological research

authors： Botchkarev VA,Eichmüller S,Peters EM,Pietsch P,Johansson O,Maurer M,Paus R

更新日期：1997-04-01 00:00:00

abstract：:Photodynamic therapy (PDT) in dermatology has been proven to be a successful noninvasive therapeutic modality for treating skin cancer. To facilitate its clinical introduction, the development of topical photosensitizers is necessary to avoid generalized, cutaneous photosensitivity. Therefore the penetration of synthe...

journal_title：Archives of dermatological research

authors： Karrer S,Abels C,Szeimies RM,Bäumler W,Dellian M,Hohenleutner U,Goetz AE,Landthaler M

更新日期：1997-02-01 00:00:00

abstract：:The internal stratum corneum lipid composition was investigated in relation to depth in vivo in healthy human volunteers by extraction following one, three or five strippings. Automated multiple development high-performance thin-layer chromatography (AMD-HPTLC) and gas chromatography (GC) followed by normalized princi...

journal_title：Archives of dermatological research

authors： Bonté F,Saunois A,Pinguet P,Meybeck A

更新日期：1997-01-01 00:00:00

abstract：:We investigated the effect of interferon-gamma (IFN-gamma) on skin equivalents. Keratinocytes from involved and uninvolved skin from psoriatic subjects and from healthy subjects were grown on preproduced dermal equivalents (DE) containing fibroblasts from healthy skin or psoriatic lesions. Healthy keratinocytes were a...

journal_title：Archives of dermatological research

authors： Fransson J,Shen Q,Scheynius A,Hammar H

更新日期：1996-12-01 00:00:00

abstract：:Although cell death by apoptosis has been recognized as an important control mechanism in the maintenance of tissue homeostasis and in the elimination of cells with damaged DNA, information on the induction and characteristics of apoptosis in keratinocytes is rather scarce. Apoptotic mechanisms may play an important r...

journal_title：Archives of dermatological research

authors： Henseleit U,Rosenbach T,Kolde G

更新日期：1996-10-01 00:00:00